I’ve blogged about the possible link between Tamoxifen and memory/dementia:
here and here.
This is a link to an interesting article on this topic:
http://www.sciencedirect.com/science/article/pii/S0091305701006566.
Another interesting article – see the abstract at the start:
http://www.faceblind.org/social_perception/papers/zbasseda/zbasseda-Tamoxifen.pdf
Perhaps most interestingly, Tamoxifen appears to be a drug that researchers turn to when they wish, for whatever reason, to impair the memory of mice: as this link shows – and it’s an interesting article in its own right: ‘After being given tamoxifen (perhaps best known as a breastcancer drug) for eight days, an otherwise normally developing mouse had more than 80 percent fewer new neural stem cells in its hippocampus (a structure in the brain’s frontal region linked to short-term memory).’ And whereabouts in the brain is Alzheimer’s first detected? In the hippocampus, I believe.
Ray
My wife has a 'condition'. Many people who have to have labels would say she has dementia. She first attended a memory clinic in 2000, aged 52, and has suffered a marked decline recently. We have been trying to follow the advice of our Guru: 'Live a Good Life'. It's not easy but there doesn't seem to be any better advice around. I found myself saying to a friend that I would find my wife's condition very interesting if I wasn't so involved. I've realised now that I do find it, and the issues it raises, interesting. And that there's nothing wrong with that. It's one of the things that keeps me going. Not that I have any choice. I think more and more that I'm a very rational person (though I'm not claiming that I always behave rationally). I have to try and make sense of things. In my current situation, this is quite a challenge. We all need challenges, they say. I'm hoping this blog might help me, and maybe others, in some way. If I'm wrong, it won't last very long.
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on May 26, 2017 at 8:26 am Brain