Palmo-plantar pustulosis (PPP) is a rare form of pustular psoriasis. It is primarily seen in adults and on certain areas of the body such as hands and feet. It can be triggered by many things and can be incredibly distressing for people who experience the condition.

The APRICOT Study Team at Guy’s and Thomas’ NHS Foundation Trust are looking for people with the condition to participate in a new trial to determine whether 8 weeks of daily anakinra injections are an effective treatment for PPP.

Anakinra has been shown to have beneficial effects in early studies of patients with pustular psoriasis, it has a good safety profile, and it is already licensed for use in other inflammatory conditions (for example rheumatoid arthritis).

What’s involved in the trial?

The first stage of the study is designed as a randomised, double blind, placebo-controlled clinical trial. Patients who have completed the 8 week treatment period schedule in the clinical trial, as well as the 12 week follow-up visit, can take part in an optional 8 week period of anakinra treatment, as an Open Label Extension to the trial.

Your research nurse will provide you with all the necessary supplies, support and instructions and every day you will be asked to fill out your diary card as a record. You will also be seen in an outpatient clinic 3 times after your first dose at week 1,4 and 8.

The Study is open to participants in the following locations:

London Salford Newcastle
Cardiff Derby Dundee
Bradford Liverpool Lancaster
Dudley Britstol Cambridge
Poole Harlow Nottingham
Exeter Glasgow Broomfield Hospital (Essex)

You will be reimbursed for reasonable travel expenses during the course of the study.
If you are interested in taking part in this study, contact the APRICOT team for more information by email: or telephone: 07717 697 435 or 020 7188 7188 #56073

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