A major breakthrough in creating effective new treatments for allergic asthma has been discovered by Asthma UK funded scientists at King’s College London.
The discovery is the culmination of over fifteen years of Asthma UK-funded research, and the findings are published in the journal Nature Structural & Molecular Biology.
The painstaking work conducted by a team of scientists led by Professor Brian Sutton at the MRC-Asthma UK Centre in Allergic Mechanisms of Asthma at King’s College London, revealed the precise shape of an important molecule called IgE as it binds to receptor proteins on the surface of mast cells in the lungs.
Scientists built up a picture of IgE’s shape down to the location of each individual atom by firing X-rays at purified protein crystals and measuring how the rays were deflected. Using this technique they were also able to reveal how IgE moves and twists as it attaches to the receptor …