Search found 21 matches

Search found 21 matches
by Dr Graham Beastall
Fri Feb 03, 2012 9:11 pm
Forum: Hypothyroidism (Underactive Thyroid)
Topic: Conversion and assimilation of thyroid hormones
Replies: 1
Views: 4124

Re: Conversion and assimilation of thyroid hormones

A primary cause of reduced conversion of T4 to T3 is extremely rare. Likewise receptor defects that alter the uptake of thyroid hormone into the cell are extremely rare. In contrast intercurrent illness of a non-thyroidal nature can bring about subtle effects on thyroid hormone metabolism. The best ...
by Dr Graham Beastall
Fri Feb 03, 2012 8:57 pm
Forum: Hypothyroidism (Underactive Thyroid)
Topic: Reverse T3
Replies: 1
Views: 4682

Re: Reverse T3

When I started measuring thyroid hormones in my laboratory 35 years ago I established an assay for reverse T3 (rT3). Several other laboratories did the same. The assay helped us a little in understanding the cause and time course of non-thyroidal illness but as experience of the assay grew there was...
by Dr Graham Beastall
Fri Feb 03, 2012 8:40 pm
Forum: Hypothyroidism (Underactive Thyroid)
Topic: so in your opinion what is an ideal TSH
Replies: 3
Views: 5624

Re: so in your opinion what is an ideal TSH

It is not possible to answer the question 'what is an ideal TSH?' The best advice available in thyroid hormone replacement therapy is to reduce or alleviate symptoms whilst maintaining the serum TSH within the reference range (broadly 0.5-4.5mU/L). In most patients this can be achieved. However, in ...
by Dr Graham Beastall
Fri Feb 03, 2012 8:23 pm
Forum: Talking with doctors
Topic: Two physiologically different definitions for HypoT!
Replies: 1
Views: 8065

Re: Two physiologically different definitions for HypoT!

Mirielle, I will reply but I suspect that I may not be able to answer your query to your satisfaction. I hear a lot of cases in which patients claim to be suffering from poor peripheral conversion of T4 into T3. Usually there is no supporting evidence and it is a diagnosis of exclusion in someone wh...
by Dr Graham Beastall
Tue Jan 31, 2012 10:17 am
Forum: Hypothyroidism (Underactive Thyroid)
Topic: TSH - Why it's useless!
Replies: 8
Views: 6168

Re: TSH - Why it's useless!

I'm sorry but I cannot allow this assassination of the TSH test to go without comment. The scientific and medical literature contains many hundreds of authoritative articles that attest to its proven clinical value. If it is as bad as you say then why were more than 20 million TSH tests performed in...
by Dr Graham Beastall
Tue Jan 31, 2012 9:53 am
Forum: Hypothyroidism (Underactive Thyroid)
Topic: Thyroxine does not work
Replies: 12
Views: 8292

Re: Thyroxine does not work

Galathea, For reading on the non-thyroidal illness syndrome I suggest that you read Chapter 5b of the Thyroid Manager (http://www.thyroidmanager.org). This Chapter gives an explanation of the syndrome illustrated by some of the conditions with which it is associated. There is also a balanced conside...
by Dr Graham Beastall
Mon Jan 30, 2012 6:00 pm
Forum: Hypothyroidism (Underactive Thyroid)
Topic: Thyroxine does not work
Replies: 12
Views: 8292

Re: Thyroxine does not work

I am happy to pick up this chain of messages. The reality is that thyroxine does work for hundreds of thousands of people in the UK. If it works for them then of course, they are happy and they do not complain. There are a small number of people for whom the optimisation of thyroxine replacement pro...
by Dr Graham Beastall
Mon Jan 30, 2012 2:43 pm
Forum: Hypothyroidism (Underactive Thyroid)
Topic: HIGH TPO ANTIBODIES
Replies: 1
Views: 2129

Re: HIGH TPO ANTIBODIES

A high concentration of TPO antibodies is a marker of autoimmune disease within the thyroid gland. It provides a marker of risk of progression from normal thyroid status to having a thyroid disorder. In the case of primary hypothyroidism an increased level of TPO antibodies is a reason for closer mo...
by Dr Graham Beastall
Mon Jan 30, 2012 2:26 pm
Forum: Hypothyroidism (Underactive Thyroid)
Topic: TSH refernece ranges
Replies: 10
Views: 6927

Re: TSH refernece ranges

The comparison of diabetes with primary hypothyroidism is interesting. It is worth noting that no matter how severe the symptoms a diagnosis of diabetes cannot be made without clear biochemical evidence of abnormal glucose metabolism. Both diabetes and primary hypothyroidism are commonly seen in the...
by Dr Graham Beastall
Fri Jan 27, 2012 2:27 pm
Forum: Hypothyroidism (Underactive Thyroid)
Topic: TSH levels when monitoring treatment for hypothyroidism
Replies: 7
Views: 5843

Re: TSH levels when monitoring treatment for hypothyroidism

Thank you ipman. There are peer reviewed publications examining the relationship between long term TSH suppression and the impact on bones and heart. The results of these studies are not completely consistent because it seems to depend on the initial thyroid disease, the method of treatment, the len...
Search found 21 matches