Dr Millar said: "I agree with Charles that "brain fog" can be one of the most distressing, disabling and frustrating features of CFS/ME and as we have no physiological mechanism by which we can explain it, we do not have any potential targets for drug development at present." Fir...

Very good point. I seem to remember some years ago that MEA found out that legally there is no difference between prescribing exercise or a drug. However, if an ME patient said they were worse with GET it is quite likely the doctor or physio who prescribed it would merely tell them, the GMC etc it w...

Dear Jessica, You state that: “Graded Exercise Therapy (GET) appears to work for people not because it’s reversing deconditioning, but because it’s changing the perception of effort. The most scientifically convincing explanation is therefore not to do with any particular muscle abnormality, but rat...