There is no evidence from clinical trials to indicate that vitamin B12 injections are an effective form of treatment for ME/CFS The use of vitamin B12, including one (very small) clinical trail (Kaslov et al) that failed to demonstrate any benefit, is summarised in the Treatment section of the MEA b...

You can look at dorsal columns with MRI:

http://jnnp.bmj.com/content/71/4/488.full

but this has not been done in ME/CFS

There are a number of possible reasons why people with ME/CFS sometimes report breathing problems This spectrum covers anxiety and hyperventilation (overbreathing) right through to factors involved in sleep apnoea There is also the possibility that there may be a co-existent lung disease present tha...

This finding (ie dorsal root ganglionitis/DRG) is not indicative of a massive infection in the body DRG is also found in Sjogren's Syndrome (not recognised as an infective condition) where it has been linked to what is called a peripheral neuropathy And it could well be that this link is relevant to...

Post mortems that we have reported on so far: Neuropathology of post-infectious chronic fatigue syndrome Journal of the Neurological Sciences 2009 (S60-S61) Cader S., O'Donovan D.G., Shepherd C., Chaudhuri A. Abstract Purpose: The pathogenesis of severe and relapsing chronic fatigue after viral or b...

MEA clinical guidelines booklet:

http://www.meassociation.org.uk/?p=4038

Contact MEA HQ if you want a free copy sent to your GP - we still have funding available to do this work

Chris Thanks for these very helpful practical suggestions I would agree that fatigue in the small muscles that control eye movements may well be relevant here Interesting to note that people with ME/CFS quite often report blepharospasm - twitching or abnormal movements in the eyelids, especially whe...

I am obviously following all these developments and am in contact with Professor Edwards at UCL Professor Edwards is currently looking at the feasibility of a clinical trial taking place at UCL He is (very wisely) collecting information from a wide variety of sources and going to Norway next month t...

Yes, quite possible

A boom and bust approach to management is almost certainly going to have a very negative impact on the chances of improvement/recovery occurring

Nobody is certain how gabapentin acts to reduce pain sensation. But it may well be due to the way in which it affects chemical transmitter systems (= neurotransmitters) in the brain that are involved in the recognition and processing of messages about pain that are constantly being passed to the bra...